According to information obtained from local sources, the base at Harab Jir Airport, where US forces are stationed in the town of Yarubiyeh in Hasakah, was attacked by an unidentified drone with explosives on board.
While it is learned that the base was targeted in the attack, there is no information on any casualties.
The US has not yet made a statement regarding the attack.
In recent days in Syria, the US military bases in the Tenef region, the Malikiyya district near the Iraqi border, the Shaddadi district of Hasakah province and the Deir ez-Zor province have been attacked by unidentified armed unmanned aerial vehicles (UAVs) and surface-to-surface weapons.
Iranian-backed groups occasionally attack the US bases on the east bank of the Euphrates River with rockets, drones and UCAVs.
On October 19, Iranian state television aired a report on how Tehran's regional allies, which it calls "resistance forces," could attack Israel if it does not halt its attacks on Gaza.
The video showed on a map that Israel would be simultaneously targeted by Hezbollah from the north, militias in Iraq and Syria from the east, and the Houthis in Yemen from the south with missiles and drones.
Iran has repeatedly called at the highest level for an end to Israel's attacks on Gaza.
In a speech on October 17, Iran's Supreme Leader Ayatollah Ali Khamenei said that the "forces of resistance" would mobilize if Israel's attacks continued.
Foreign Minister Hossein Amir Abdollahian also said on October 19 that the conflict could spread to the region.
Iran refers to Lebanese Hezbollah, the militias it supports in Syria and Iraq, and the Houthis in Yemen as "resistance forces".