Speaking at the opening of the G77+China summit in Kampala, Uganda, Guterres said, "Israel's military operations have spread mass destruction and caused unprecedented levels of civilian deaths."
"The Middle East is a matchbox. We must do all we can to prevent the conflict from spreading throughout the region."
The Ministry of Health in Gaza announced that more than 25,000 Palestinians have been killed so far in the Israeli offensive that began on October 7.
Guterres also said that the Israeli government's rejection of the two-state solution is unacceptable and that Palestinians have the right to statehood. The UN Secretary-General said Israel's stance would prolong "a war that has already become a major threat to world peace and security."