Authorities said part of the crane came loose while crews were trying to raise its height.
Footage from the scene shows the massive metal structure falling onto a car crossing a bridge, crushing its front end.
The construction worker who fell with the crane section lost his life.
Two of the injured were hospitalized, while three others were treated at the scene.
Authorities say they do not yet know what caused the crane section to fall and have closed the Southeast 3rd Avenue bridge indefinitely while they investigate the scene.
