In a post on his LinkedIn account, Kempczinski claimed that the boycott campaign against the restaurant chain was "disinformation-driven".
Describing the allegations against McDonald's as "sad and unfounded," Kempczinski said, "In every country we operate in, including Muslim countries, McDonald's is represented by local operators. They work tirelessly to serve their communities and employ thousands of people."
Boycotts started after the war
Following the start of the Gaza war, a number of brands, including McDonald's and Starbucks, have been the target of boycott campaigns for their alleged links to Israel.
In October, McDonald's Israel posted photos on its social media accounts announcing that it was providing free meals to the Israeli army, which was condemned by McDonald's in Muslim-majority countries.
Reuters reported that some Western brands targeted by boycott campaigns felt the impact of the boycott, especially in Egypt, Jordan and Malaysia.
McDonald's, which has 40,275 restaurants in more than 100 countries, generated revenues of $23.1 billion in fiscal 2022.
After Kempczinski's boycott announcement, McDonald's shares fell sharply.