The Koniko gas plant, where US forces are stationed, was attacked with surface-to-surface weapons.
It is not known whether there were any casualties in the attack.
US officials have not yet commented on the attack.
Since the beginning of the year, US military bases in Hasakah and Deir ez-Zor have been frequently targeted with rockets and kamikaze drones of unknown origin.
Deir Ezzor lands east of the Euphrates River are under the occupation of the US-backed terrorist organization PKK/YPG, while the provincial center and other rural areas are under the control of the Assad regime and Iran-backed groups.